What we do
The goal of the lab is to understand how distributed neural circuits regulate feeding and motivated behavior and how these processes are disrupted by external factors, such as diet. The lab uses calcium imaging, electrophysiology, and viral based genetic tools to perturb and observe neural activity.
Longitudinal deep brain 2p calcium imaging in feeding, reward, and obesity
We measure the relationship between motivated behavior and neuronal activity using deep brain two-photon calcium imaging and longitudinally assess how this relationship evolves during diet-induced obesity.
Electrophysiology in subcortical feeding circuits
We use patch-clamp electrophysiology to characterize molecularly defined cell types and probe how diet and feeding hormones alter their function.
Functional perturbations during motivated behavior
We utilize viral and pharmacological tools to perturb neuronal activity and measure the effects on motivated behavior.
Viral-mediated neuroanatomical tracing
We employ a variety of viral tools to map the functional and anatomical makeup of the hypothalamus and associated brain regions.